General
Preferred name
LY354740
Synonyms
Eglumetad hydrate ()
eglumegad ()
(rel)-Eglumegad ()
Eglumegad (hydrochloride) ()
EGLUMETAD ()
(rel)-LY354740 ()
(rel)-Eglumetad ()
LY354740 (hydrochloride) ()
Eglumetad (hydrochloride) ()
LY 354740 ()
[3H]eglumegad ()
Eglumetad anhydrous ()
LY-354740 ()
LY354740 hydrochloride ()
EGLUMETAD ANHYDROUS ()
P&D ID
PD012278
CAS
176199-48-7
176027-90-0
Tags
available
drug candidate
Drug indication
Anxiety disorder
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION LY 354740 is a selective group II mGlu receptors agonist with EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors. It shows antianxiety and antiaddictive activity. (BOC Sciences Bioactive Compounds)
DESCRIPTION LY354740 is an agonist of the group II metabotropic glutamate receptor (mGluR). LY354740 also shows efficacy in animal models of anxiety, epilepsy, and withdrawal from nicotine and morphine. (Enamine Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
13
BOC Sciences Bioactive Compounds
ly-354740-cas-176199-48-7-item-85924
Cayman Chemical Bioactives
24215
ChEMBL Drugs
CHEMBL8759
Drug Repurposing Hub
DrugMAP
DM08BIZ
Enamine Bioactive Compounds
EBC-361044
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101888
EUbOPEN Chemogenomics Library
EUB0000973
Guide to Pharmacology
1393
1396
MedChem Express Bioactive Compound Library
HY-18941
HY-18941B
HY-18941C
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
185.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
0
cLogP
-0.49
TPSA
100.62
Fraction CSP3
0.75
Chiral centers
4.0
Largest ring
5.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
GRM2 agonist
GRM3 agonist
glutamate receptor agonist
Target
GRM2, GRM3, GRM6, GRM8
mGluR
Pathway
GPCR/G protein
Neuronal Signaling
Recommended Cell Concentration
100 nM
Source data