General
Preferred name
AMI-1
Synonyms
P&D ID
PD012277
CAS
20324-87-2
134-47-4
Tags
available
drug candidate
obsolete probe
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 ¦ÌM and 3.0 ¦ÌM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding[1].
PRICE 29
DESCRIPTION AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 ??M, for yeast Hmt1p, and human PRMT1).
DESCRIPTION AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1). (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
6
Axon Medchem Screening Library
2863
DrugMAP
DM4MXOB
MedChem Express Bioactive Compound Library
HY-18962
Obsolete Compounds
ami-1
Selleckchem Bioactive Compound Library
ami-1
TargetMol Bioactive Compound Library
T2352
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
547.99
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
-3.14
TPSA
195.99
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.15
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
Histone methyltransferase
PRMT1
yeast Hmt1p
PRMT inhibitor
Histone Methyltransferase,PRMT
MOA
Histone Methyltransferase inhibitor
Pathway
Chromatin/Epigenetic
Epigenetics
Source data