General
Preferred name
INDIPLON
Synonyms
NBI 34060 ()
Amitriptyline+ketamine ()
NBI-34060 ()
Calenthys ()
CL-285489 ()
Indiplon ()
P&D ID
PD012270
CAS
325715-02-4
Tags
available
drug candidate
drug
Drug indication
Fibromyalgia
Postherpetic neuralgia
Neuropathic pain
Insomnia
Diabetic neuropathy
Drug Status
investigational
approved
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Subtype-selective GABAA receptor positive allosteric modulator (Tocriscreen Plus)
DESCRIPTION Subtype-selective GABAA receptor positive allosteric modulator (Tocriscreen Total)
Compound Sets
15
AdooQ Bioactive Compound Library
A13769
Axon Medchem Screening Library
1121
Cayman Chemical Bioactives
11638
ChEMBL Drugs
CHEMBL262075
Concise Guide to Pharmacology 2017/18
4221
Concise Guide to Pharmacology 2019/20
4221
Concise Guide to Pharmacology 2021/22
4221
Drug Repurposing Hub
DrugBank
DB12590
DrugMAP
DMOPGHQ
DMF50XJ
DrugMAP Approved Drugs
DMOPGHQ
Guide to Pharmacology
4221
ReFrame library
Tocriscreen Plus
3597
Tocriscreen Total
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
376.1
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
3.67
TPSA
67.57
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
GABRA1
GABAA modulator
MOA
benzodiazepine receptor agonist
Therapeutic Class
Analgesics
Source data