General
Preferred name
ONO-AE3-208
Synonyms
ONO AE3 208 ()
AE 3-208 ()
ONO-AE3-208 (sodium salt) ()
P&D ID
PD012225
CAS
402473-54-5
2309931-05-1
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ONO-AE3-208 is a high affinity, selective EP4 receptor antagonist. (GtoPdb)
DESCRIPTION High affinity and selective EP4 antagonist (Tocriscreen Plus)
DESCRIPTION Functionally selective M1 agonist (Tocris Bioactive Compound Library)
Compound Sets
10
Cayman Chemical Bioactives
14522
16108
Concise Guide to Pharmacology 2017/18
1942
Concise Guide to Pharmacology 2019/20
1942
Concise Guide to Pharmacology 2021/22
1942
Concise Guide to Pharmacology 2023/24
1942
DrugMAP
DMEY7T4
Guide to Pharmacology
1942
MedChem Express Bioactive Compound Library
HY-50901
Tocris Bioactive Compound Library
3565
Tocriscreen Plus
3565
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
404.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
5.0
TPSA
90.19
Fraction CSP3
0.21
Chiral centers
1.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
Prostanoid Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Target
Prostaglandin Receptor
Source data