General
Preferred name
LY404039
Synonyms
pomaglumetad ()
LY2140023 (LY404039) ()
LY-404039 ()
pomaglumetad (LY404039) ()
Ly 404039 ()
LY-404039, (-)- ()
P&D ID
PD012224
CAS
635318-11-5
Tags
available
drug candidate
Drug indication
Schizophrenia
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION LY404039 is a potent, selective and orally active mGluR2 and mGluR3 agonist with Kis of 149 nM and 92 nM for recombinant human mGluR2 and mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects[1].
PRICE 35
DESCRIPTION LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM). (TargetMol Bioactive Compound Library)
Compound Sets
12
AdooQ Bioactive Compound Library
A10544
Cayman Chemical Bioactives
18408
ChEMBL Drugs
CHEMBL375611
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMWZIRJ
EU-OPENSCREEN Bioactive Compound Library
EOS100977
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL375611
MedChem Express Bioactive Compound Library
HY-50906
ReFrame library
Selleckchem Bioactive Compound Library
LY2140023(LY404039)
TargetMol Bioactive Compound Library
T6022
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
235.02
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
0
cLogP
-2.1
TPSA
134.76
Fraction CSP3
0.71
Chiral centers
4.0
Largest ring
5.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mGluR
Rat neurons expressing native mGlu2/3
Recombinant human mGlu2
Recombinant human mGlu3
GRM3
GluR
MOA
glutamate receptor agonist
Pathway
Endocrinology/Hormones
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data