General
Preferred name
GALETERONE
Synonyms
VN-124-1 ()
TOK-001 ()
VN/124-1 ()
VN 124 ()
TOK-001 (Galeterone) ()
VN-124 ()
TOK 001 ()
VN/124 ()
P&D ID
PD012209
CAS
851983-85-2
Tags
drug candidate
natural product
available
Drug indication
Prostate cancer
Drug Status
investigational
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent farnesyl diphosphate (FPP) synthase inhibitor (Tocris Bioactive Compound Library)
Cell lines
10
Organisms
0
Compound Sets
17
AdooQ Bioactive Compound Library
A11138
Cayman Chemical Bioactives
17586
ChEMBL Drugs
CHEMBL2105738
Concise Guide to Pharmacology 2017/18
8638
Concise Guide to Pharmacology 2019/20
8638
Concise Guide to Pharmacology 2021/22
8638
Concise Guide to Pharmacology 2023/24
8638
Drug Repurposing Hub
DrugBank
DB12415
DrugMAP
DMVJWPR
EU-OPENSCREEN Bioactive Compound Library
EOS101217
Guide to Pharmacology
8638
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2105738
MedChem Express Bioactive Compound Library
HY-70006
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T6509
Tocris Bioactive Compound Library
6108
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
388.25
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
6
Aromatic Ring Count
2
cLogP
5.81
TPSA
38.05
Fraction CSP3
0.58
Chiral centers
6.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Metabolism
Metabolic Enzyme/Protease
Target
Androgen Receptor
CYP17
AR, CYP17A1
Primary Target
Cytochrome P450
MOA
Inhibitor
Androgen Receptor Antagonists
Cytochrome P450 CYP17 (17alpha-Hydroxylase/C17-20 Lyase) Inhibitors
Androgen Receptor modulator
Member status
member
Source data