General
Preferred name
DMP-777
Synonyms
L-694,458 ()
DMP 777 ()
L-694458 ()
P&D ID
PD012197
CAS
157341-41-8
Tags
available
drug candidate
Drug indication
Cystic fibrosis
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
DESCRIPTION
DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
ReFrame library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
564.29
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
5
Aromatic Ring Count
2
cLogP
4.41
TPSA
100.65
Fraction CSP3
0.52
Chiral centers
2.0
Largest ring
6.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
MPO
Elastase
MOA
Elastase inhibitor
Pathway
Metabolic Enzyme/Protease
Source data
