General
Preferred name
TEBIPENEM PIVOXIL
Synonyms
ME1211 ()
Orapenem ()
TEBIPENEM PIVOXIL HYDROBROMIDE ()
L084 ()
L-084, ME1211,TBPM-PI,LJC 11036 ()
LJC 11,084 ()
TBPM-PI ()
L-084 ()
LJC 11084 ()
LJC-11084 ()
ME-1211 ()
SPR994 ()
TBPM-PI-HBr ()
SPR-994 ()
P&D ID
PD012181
CAS
161715-24-8
Tags
prodrug
drug candidate
natural product
drug
available
Drug indication
Respiratory tract infection
Drug Status
investigational
approved
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tebipenem pivoxil is an orally available pivaloyloxymethyl ester prodrug of the β-lactam antibacterial tebipenem . The ester bond is cleaved, releasing active tebipenem (PubChem CID 9800194; LJC-11036). The drug has Gram-negative activity. Tebipenem pivoxil hydrobromide (SPR994) is another formulation of the same drug.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
497.17
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
0
cLogP
1.67
TPSA
108.74
Fraction CSP3
0.73
Chiral centers
4.0
Largest ring
5.0
QED
0.33
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
antibiotic
CNR1
Bacterial
Penicillin-binding protein (PBP)
Antibiotics
Disease Area
infectious disease, otolaryngology
Indication
pneumonia, otitis
MOA
bacterial cell wall synthesis inhibitor
Source data
