General
Preferred name
MIZOLASTINE
Synonyms
Mizolastine (dihydrochloride) ()
SL 850324 ()
Mizolastine dihydrochloride ()
Mizollen ()
Mizolastina ()
P&D ID
PD012164
CAS
108612-45-9
1056596-82-7
Tags
available
drug
Approved by
MHRA
First approval
1998
2003
Drug indication
Allergic rhinitis
allergic disease
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Mizolastine is a highly selective, long-acting second generation histamine H1 receptor antagonist that is used clinically as an antiallergy medication. It does not cross the blood-brain barrier and does not bind the muscarinic cholinergic M1 receptor .
(GtoPdb)
PRICE
29
DESCRIPTION
Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165, VEGF120, TNF-¦Á and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial[1][2][3].
DESCRIPTION
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Mizolastine (SL 850324) (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives.
(TargetMol Bioactive Compound Library)
DESCRIPTION
The dihydrochloride salt form of Mizolastine which is effective in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis and other allergy symptoms for playing the role as a histamine H1-receptor antagonis. IC50: 47nM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
432.21
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
4
cLogP
3.41
TPSA
70.05
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histamine Receptor
HRH1
H1 receptor
Pathway
Immunology/Inflammation
GPCR/G protein
Neuronal Signaling
Neuroscience
Indication
urticaria, allergic rhinitis
MOA
Histamine Receptor antagonist
Therapeutic Class
Antiallergic Agents
Solubility
10 mM in DMSO
Source data
