General
Preferred name
PRANLUKAST
Synonyms
ONO-1078 ()
ONO 1078 ()
Pranlukast (hemihydrate) ()
ONO-1078 (hemihydrate) ()
Pranlukast (ONO 1078) ()
CCN 00401 ()
RS 411 ()
SB 205312 ()
SB-205312 ()
CCN-00401 ()
AZLAIRE ()
RS-411 ()
Pranlukast-d4 ()
P&D ID
PD012151
CAS
103177-37-3
150821-03-7
2713172-43-9
Tags
available
drug
Approved by
PMDA
First approval
1995
2007
Drug indication
Asthma
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Pranlukast is a leukotriene receptor antagonist (LTRA), with selectivity for cysteinyl leukotriene receptor 1 (CysLT1 receptor). It is estimated to be 4500-fold selective for CysLT1 over CysLT2 in vitro .
(GtoPdb)
DESCRIPTION
CCK1 antagonist; active in vivo
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
24
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
481.18
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
5
Aromatic Ring Count
5
cLogP
4.63
TPSA
123.0
Fraction CSP3
0.15
Chiral centers
0.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Immunology/Inflammation
NF-??b
GPCR/G protein
Metabolic Enzyme/Protease
Target
IL-5
CysLTR
NF-??B
Eosinophil cationic protein
Mucin-2
TNF-??
Leukotriene Receptor
CYSLTR1, CYSLTR2, IL5, MUC2, NFKB1, RNASE3, TNF
Endogenous Metabolite
Primary Target
Leukotriene and Related Receptors
MOA
Antagonist
Leukotriene Receptor Antagonist
Indication
bronchospasm, asthma
Therapeutic Class
Antiasthmatic Agents
Recommended Cell Concentration
None
Source data
