General
Preferred name
EPTIFIBATIDE
Synonyms
MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2 ()
{MPA}{HAR}GDWPC-NH2 ()
BRC0090 ()
Eptifibatide Acetate ()
Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2 ()
Integrilin ()
Integrelin ()
Eptifibatide ()
P&D ID
PD012110
CAS
188627-80-7
1248559-53-6
148031-34-9
Tags
available
drug
Approved by
EMA
FDA
First approval
1998
Drug indication
Acute cardiac ischemic events
Drug Status
approved
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Eptifibatide is a synthetic cyclic hexapeptide inhibitor of the integrin αIIbβ3 protein complex.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
23
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
831.32
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
11
Rotatable Bonds
10
Ring Count
4
Aromatic Ring Count
2
cLogP
-1.84
TPSA
323.89
Fraction CSP3
0.51
Chiral centers
5.0
Largest ring
23.0
QED
0.05
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
glycoprotein IIb-IIIa receptor inhibitor
Inhibitors of Blood Coagulation Pathways
Integrin alphaIIbbeta3 (Fibrinogen gpIIb/IIIa) Antagonists
"Inhibitors of Blood Coagulation Pathways
Integrin alphaIIbbeta3 (Fibrinogen gpIIb/IIIa) Antagonists"
Platelet aggregation Inhibitor
Target
Integrin alpha-IIb/beta-3
ITGA2B, ITGB3
Integrin
5-alpha Reductase
Member status
member
Indication
acute coronary syndrome (ACS), percutaneous coronary intervention (PCI)
Therapeutic Class
Anticoagulants
Pathway
cytoskeleton
Source data
