General
Preferred name
RAMATROBAN
Synonyms
BAY u3405 ()
BAY-u 3405 ()
BAY u 3405 ()
BAY-U-3405 ()
EN 137774 ()
Baynas ()
EN-137774 ()
P&D ID
PD012103
CAS
116649-85-5
Tags
available
drug
Drug indication
Perennial allergic rhinitis
Drug Status
investigational
approved
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION D4 and 5-HT2A antagonist; antipsychotic (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
22
AdooQ Bioactive Compound Library
A13751
Cayman Chemical Bioactives
10156
ChEMBL Drugs
CHEMBL361812
Concise Guide to Pharmacology 2017/18
1911
Concise Guide to Pharmacology 2019/20
1911
Concise Guide to Pharmacology 2021/22
1911
Concise Guide to Pharmacology 2023/24
1911
Drug Repurposing Hub
DrugBank
DB13036
DrugCentral
2354
DrugCentral Approved Drugs
2354
DrugMAP
DMB8UQ3
EU-OPENSCREEN Bioactive Compound Library
EOS101658
Guide to Pharmacology
1910
1911
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL361812
MedChem Express Bioactive Compound Library
HY-B0745
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
ramatroban
TargetMol Bioactive Compound Library
T2396
Tocris Bioactive Compound Library
2732
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
416.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
3.09
TPSA
88.4
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Metabolism
DNA Damage/DNA Repair
GPCR/G protein
Target
CRTH2
TXA2R
PTGDR2, TBXA2R
Prostaglandin Receptor
Primary Target
Prostanoid Receptors
MOA
Antagonist
GPR44 antagonist
PTGDR antagonist
CRTH2 Receptor Antagonists
CCL2 Expression Inhibitors
Prostanoid TP Antagonists
prostanoid receptor antagonist
Member status
member
Indication
coronary artery disease (CAD), asthma
Disease Area
cardiology, pulmonary
Source data