General
Preferred name
HALCINONIDE
Synonyms
Halcimat ()
Halciderm ()
Halcinonida ()
SQ-18566 ()
NSC-758413 ()
SO-18566 ()
SO 18566 ()
SQ 18566 ()
Halog-E ()
Halog ()
P&D ID
PD012088
CAS
3093-35-4
161491-04-9
Tags
available
drug
Approved by
FDA
First approval
1974
Drug indication
Skin disease
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA The precise mechanism of action of topical corticosteroids is unclear. However they possess anti-inflammatory, antipruritic, and vasoconstrictive actions.; ; New research indicates that halcinonide activates MBP (myelin basic protein) expression via smoothened receptor activation. This finding suggests that halcinonide could be used in the treatment of multiple sclerosis therapy as an alternative to Dexamethasone or Methylprednisolone.
DESCRIPTION Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.
PRICE 33
DESCRIPTION Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent. (BOC Sciences Bioactive Compounds)
DESCRIPTION Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations. (TargetMol Bioactive Compound Library)
Compound Sets
20
BOC Sciences Bioactive Compounds
halcinonide-cas-3093-35-4-item-84-65722
Cayman Chemical Bioactives
23780
10005278
ChEMBL Approved Drugs
CHEMBL1200845
ChEMBL Drugs
CHEMBL1200845
Drug Repurposing Hub
DrugBank
DB06786
DrugBank Approved Drugs
DB06786
DrugCentral
4507
DrugCentral Approved Drugs
4507
DrugMAP
DMGLAX1
DrugMAP Approved Drugs
DMGLAX1
EU-OPENSCREEN Bioactive Compound Library
EOS100725
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200845
MedChem Express Bioactive Compound Library
HY-B0877
NCATS Inxight Approved Drugs
SI86V6QNEG
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
halcinonide
TargetMol Bioactive Compound Library
T0107
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
454.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
0
cLogP
3.89
TPSA
72.83
Fraction CSP3
0.83
Chiral centers
8.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
GR
Glucocorticoid Receptor agonist
Indication
corticosteroid-responsive dermatoses
Target
NR3C1
SMO
Immunology & Inflammation related
Glucocorticoid Receptor
Pathway
Endocrinology/Hormones
Stem Cells
Stem Cell/Wnt
Source data