General
Preferred name
HALCINONIDE
Synonyms
SQ-18566 ()
Halciderm ()
Halcimat ()
Halcinonida ()
NSC-758413 ()
SO-18566 ()
Halog-E ()
SQ 18566 ()
SO 18566 ()
Halog ()
P&D ID
PD012088
CAS
3093-35-4
161491-04-9
Tags
natural product
drug
available
Approved by
FDA
First approval
1974
Drug Status
investigational
approved
withdrawn
Drug indication
Skin disease
Anti-Inflammatory (topical)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA The precise mechanism of action of topical corticosteroids is unclear. However they possess anti-inflammatory, antipruritic, and vasoconstrictive actions.; ; New research indicates that halcinonide activates MBP (myelin basic protein) expression via smoothened receptor activation. This finding suggests that halcinonide could be used in the treatment of multiple sclerosis therapy as an alternative to Dexamethasone or Methylprednisolone.
DESCRIPTION Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent. (BOC Sciences Bioactive Compounds)
Compound Sets
20
BOC Sciences Bioactive Compounds
halcinonide-cas-3093-35-4-item-84-65722
Cayman Chemical Bioactives
23780
10005278
ChEMBL Approved Drugs
CHEMBL1200845
ChEMBL Drugs
CHEMBL1200845
Drug Repurposing Hub
DrugBank
DB06786
DrugBank Approved Drugs
DB06786
DrugCentral
4507
DrugCentral Approved Drugs
4507
DrugMAP
DMGLAX1
DrugMAP Approved Drugs
DMGLAX1
EU-OPENSCREEN Bioactive Compound Library
EOS100725
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200845
MedChem Express Bioactive Compound Library
HY-B0877
NCATS Inxight Approved Drugs
SI86V6QNEG
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
halcinonide
TargetMol Bioactive Compound Library
T0107
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
454.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
0
cLogP
3.89
TPSA
72.83
Fraction CSP3
0.83
Chiral centers
8.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Stem Cell/Wnt
Target
Glucocorticoid Receptor
NR3C1
SMO
Immunology & Inflammation related
MOA
GR
Glucocorticoid Receptor agonist
Indication
corticosteroid-responsive dermatoses
Source data