General
Preferred name
vincamine
Synonyms
Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan ()
Cetal retard ()
Vincagil ()
NSC-91998 ()
Arteriovinca ()
Vincafor ()
Cetal ()
Vraap ()
Oxygeron ()
Angiopac ()
Pervincamine ()
Vincimax ()
Vincamina ()
P&D ID
PD012069
CAS
1617-90-9
Tags
available
drug
natural product
Drug indication
Cerebrovascular disease
Cardiovascular disease
Drug Status
approved
withdrawn
experimental
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation[1]. Vincamine is a GPR40 agonist and acts as a ¦Â-cell protector by ameliorating ¦Â-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research[2].
DESCRIPTION
Vincamine is an alkaloid that has been isolatyed from the periwinkle plant (Vinca minor).
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
354.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
2
cLogP
2.95
TPSA
54.7
Fraction CSP3
0.57
Chiral centers
3.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CHRM1, CHRM2, CHRM3, CHRM4
Free Fatty Acid Receptor
MOA
Adrenergic Receptor antagonist
ATC
C04AX07
Toxicity type
hematological
Pathway
GPCR/G protein
Source data
