General
Preferred name
GINSENOSIDE RB1
Synonyms
Gypenoside Ⅲ ()
Gypenoside III ()
Gypenoside ¢ó ()
P&D ID
PD012060
CAS
41753-43-9
Tags
available
drug candidate
Drug Status
nutraceutical
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3¡À1.0 ¦ÌM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-¦ÊB p65 .
DESCRIPTION
Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
Cayman Chemical Bioactives
DrugBank
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
1108.6
Hydrogen Bond Acceptors
23
Hydrogen Bond Donors
15
Rotatable Bonds
16
Ring Count
8
Aromatic Ring Count
0
cLogP
-2.2
TPSA
377.29
Fraction CSP3
0.96
Chiral centers
30.0
Largest ring
6.0
QED
0.06
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Immunology/Inflammation
Membrane Transporter/Ion Channel
Microbiology/virology
NF-κB
Anti-infection
Vitamin D Related/Nuclear Receptor
NF-¦ÊB
Target
HSV
IRAK
Mitophagy
Na+/K+ ATPase
Pregnane X Receptor (PXR)
ATPase,IFN,IRAK,NF-¦ÊB,NOS,TLR,TNF-alpha
Na+/K+-ATPase
Source data
