General
Preferred name
MATRINE
Synonyms
¦Á-Matrine ()
Sophocardipine ()
Matridin-15-one ()
Vegard ()
α-Matrine ()
(+)-Matrine ()
P&D ID
PD012041
CAS
519-02-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI)[1][2][3][4][5].
Cell lines
13
Organisms
0
Compound Sets
6
AdooQ Bioactive Compound Library
A10559
Cayman Chemical Bioactives
22901
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
HY-N0164
ReFrame library
Selleckchem Bioactive Compound Library
matrine
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
248.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
0
cLogP
1.87
TPSA
23.55
Fraction CSP3
0.93
Chiral centers
4.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
OPRK1
Apoptosis
Autophagy
Ferroptosis
Mitophagy
Opioid Receptor
PINK1/Parkin
MOA
Opioid Receptor agonist
Pathway
GPCR/G protein
Neuronal Signaling
Source data