General
Preferred name
FLUMETHASONE
Synonyms
flumetasone ()
RS-2177 ()
NSC-54702 ()
flumethasone pivalate ()
RS-2177, NSC-54702,Flumetasone ()
U-10,974 ()
Flumetasona ()
Flucort ()
Flumetasone ()
U-10974 ()
P&D ID
PD012034
CAS
2135-17-3
Tags
available
drug
Approved by
FDA
Drug Status
vet_approved
approved
withdrawn
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-¦ÊB)-mediated pro-inflammatory cytokine production (TNF-¦Á, IL-1¦Â) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction). Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation[1][2][3][4].
DESCRIPTION Flumethasone (RS-2177) is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties. (TargetMol Bioactive Compound Library)
Compound Sets
15
Axon Medchem Screening Library
1169
Cayman Chemical Bioactives
24184
ChEMBL Drugs
CHEMBL1201392
Drug Repurposing Hub
DrugBank
DB00663
DrugBank Approved Drugs
DB00663
DrugCentral
4548
DrugCentral Approved Drugs
4548
EU-OPENSCREEN Bioactive Compound Library
EOS100393
MedChem Express Bioactive Compound Library
HY-B1051
NPC Screening Collection
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
flumethasone
TargetMol Bioactive Compound Library
T1124
Withdrawn 2.0
373
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
410.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.84
TPSA
94.83
Fraction CSP3
0.73
Chiral centers
9.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Glucocorticoid Receptor
NR3C1, PLA2G1B
Glucocorticoid agonist
Interleukin Related
Keap1-Nrf2
TNF Receptor
Disease Area
otolaryngology, infectious disease, dermatology
Indication
otitis, ear infections, corticosteroid-responsive dermatoses
MOA
Glucocorticoid Receptor agonist
ATC
D07AB03
D07XB01
H02AB90
Pathway
Apoptosis
Immunology/Inflammation
NF-κB
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
NF-¦ÊB
Source data