General
Preferred name
HISTAMINE
Synonyms
HISTAMINE DIHYDROCHLORIDE ()
Ergamine ()
peremin ()
Ceplene ()
Histamine 2HCl ()
Ergotidine ()
Histamine Phosphate ()
Histamine (phosphate) ()
Histamine (dihydrochloride) ()
Histamine diphosphate ()
NSC-257873 ()
Histamine hydrochloride ()
Histaminum hydrochloricum ()
Histamine dihydrocloride ()
[3H]histamine ()
NSC-33792 ()
.beta.-aminoethylglyoxaline ()
P&D ID
PD012019
CAS
51-45-6
56-92-8
6890-40-0
117932-92-0
51-74-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1939
Drug Status
investigational
approved
withdrawn
Drug indication
Diagnostic imaging
Respiratory allergy
Stimulant (gastric secretory)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Histamine is a potent pro-inflammatory mediator that is principally released from mast cells. It is also involved in regulating physiological function in the gut, and acts as a neurotransmitter.
Histamine activates carbonic anhydrases, and is most potent at the CA5A and CA1 isoforms (KA values 10 and 2100 nM respectively) . (GtoPdb)
DESCRIPTION Endogenous agonist at dopamine D1-5 receptors (Tocris Bioactive Compound Library)
DESCRIPTION Endogenous histamine receptor agonist (Tocriscreen Plus)
DESCRIPTION Endogenous neurotransmitter (LOPAC library)
DESCRIPTION Endogenous histamine receptor agonist (Tocriscreen Total)
DESCRIPTION Histamine dihydrochloride is a histamine salt used to prevent relapse in patients with acute myeloid leukemia (AML). It is also used as an active ingredient in topical analgesia for temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains and strains. (BOC Sciences Bioactive Compounds)
DESCRIPTION Histamine phosphate is a potent histamine receptor agonist and vasodilator. It acts directly on the blood vessels to dilate arteries and capillaries mediated by both H1- and H2-receptors. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
3
Compound Sets
36
BOC Sciences Bioactive Compounds
histamine-dihydrochloride-cas-56-92-8-item-84-71865
histamine-phosphate-cas-51-74-1-item-84-293994
Cayman Chemical Bioactives
33828
ChEMBL Approved Drugs
CHEMBL1533310
CHEMBL90
CHEMBL3989520
ChEMBL Drugs
CHEMBL1533310
CHEMBL90
CHEMBL3989520
Concise Guide to Pharmacology 2017/18
1204
Concise Guide to Pharmacology 2019/20
1204
Concise Guide to Pharmacology 2021/22
1204
Concise Guide to Pharmacology 2023/24
1204
Drug Repurposing Hub
DrugBank
DB05381
DrugBank Approved Drugs
DB05381
DrugCentral
1375
DrugCentral Approved Drugs
1375
DrugMAP
DM78IME
DMV7IM6
DrugMAP Approved Drugs
DM78IME
DMV7IM6
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100754
Guide to Pharmacology
1204
1247
Ki Database
HISTAMINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1533310
CHEMBL90
MedChem Express Bioactive Compound Library
HY-B0722
HY-B1204
HY-A0129
NCATS Inxight Approved Drugs
820484N8I3
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
histamine-2hcl
histamine
histamine-phosphate
TargetMol Bioactive Compound Library
T6534
T0965
The Spectrum Collection
Tocris Bioactive Compound Library
3545
Tocriscreen Plus
3545
Tocriscreen Total
Withdrawn 2.0
3
ZINC Tool Compounds
ZINC000000388081
External IDs
103
Properties
(calculated by RDKit )
Molecular Weight
111.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.09
TPSA
54.7
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
5.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Pathway
GPCR/G protein
Neuroscience
Immunology/Inflammation
Metabolic Enzyme/Protease
Neuronal Signaling
Target
HT
H1 receptor
H2 receptor
HRH1, HRH2, HRH3, HRH4
Endogenous Metabolite
Histamine Receptor
Primary Target
Histamine H1 Receptors
MOA
Agonist
NADPH Oxidase Inhibitors
Histamine Receptor Agonists
"NADPH Oxidase Inhibitors
Histamine Receptor Agonists"
Histamine Receptor agonist
Member status
member
Indication
allergic rhinitis
ATC
V
Therapeutic Class
Antiallergic Agents
Diagnostic Agents
Solubility
Soluble in Methanol (Slightly, Heated), Water (Sparingly)
Soluble in Aqueous Acid (Slightly), Water (Slightly)
Source data