General
Preferred name
ISOSORBIDE
Synonyms
Dianhydro-D-glucitol ()
D-Isosorbide ()
Isobide ()
Devicoran ()
Hydronol ()
Isosorbide ()
AT-101 ()
D-Isosorbide,Dianhydro-D-glucitol ()
Ismotic ()
1,4:3,6-dianhydro-d-glucitol ()
NSC-40725 ()
D-glucitol, 1,4:3,6-dianhydro- ()
P&D ID
PD011997
CAS
652-67-5
151380-60-8
28980-83-8
Tags
obsolete probe
natural product
drug
available
Approved by
FDA
First approval
1974
Drug Status
investigational
approved
withdrawn
Max Phase
Phase 4
Drug indication
Diuretic
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
Indicated for the prevention and treatment of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.[label]
DESCRIPTION
Isosorbide is a heterocyclic compound that is derived from glucose, used as a diuretic.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NPC Screening Collection
Obsolete Compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
146.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
0
cLogP
-1.49
TPSA
58.92
Fraction CSP3
1.0
Chiral centers
4.0
Largest ring
5.0
QED
0.44
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Indication
angina pectoris, coronary artery disease (CAD)
MOA
nitric oxide stimulant
ATC
C01DA08
C05AE02
Source data
