General
Preferred name
NSC622608
Synonyms
P&D ID
PD011832
CAS
2593254-90-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC50 value of 4.8 ¦ÌM[1].
PRICE 108
DESCRIPTION NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors. (TargetMol Bioactive Compound Library)
Compound Sets
4
Bioprocess diversity set
MedChem Express Bioactive Compound Library
HY-147311
Selleckchem Bioactive Compound Library
nsc622608
TargetMol Bioactive Compound Library
T35362
External IDs
6
Properties
(calculated by RDKit )
Molecular Weight
320.96
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
2.54
TPSA
41.63
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
5.0
QED
0.82
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Biological process
Cell polarity & morphogenesis
Target
V-domain Ig suppressor of T-cell activation (VISTA)
PD-1/PD-L1
Pathway
Immunology/Inflammation
Source data