General
Preferred name
CEFOTETAN
Synonyms
Apacef ()
Cefotetan disodium salt ()
Ici-156,834 ()
NSC-760045 ()
ICI-156834 ()
ICI 156,834 ()
Cefotetan ()
P&D ID
PD011706
CAS
69712-56-7
74356-00-6
Tags
available
drug
Drug Status
investigational
approved
Max Phase
4.0
Drug indication
osteomyelitis
First approval
1985
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cefotetan is a binding agent that targets human Raf1 kinase inhibitor protein (hRKIP). Cefotetan binds to hRKIP, reduces the binding space between hRKIP and Raf1 kinase, relieves hRKIP's inhibition of the Ras/Raf1/MEK/ERK signaling pathway, and enhances ERK phosphorylation. Cefotetan can be used to study diseases associated with dysregulated Ras/Raf1/MEK/ERK signaling pathways. Cefotetan is also a broad-spectrum antibacterial agent that disrupts cell wall synthesis by binding to bacterial penicillin-binding proteins (PBPs). It is used to study bacterial infections such as bone, skin, urinary tract, and lower respiratory tract[1][2][3].
PRICE
62
DESCRIPTION
Cefotetan (Apacef) Sodium (ICI-156834, YM-09330) is a second-generation cephalosporin, cephamycin antibiotic that is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
DrugBank
DrugBank Approved Drugs
MedChem Express Bioactive Compound Library
Other bioactive compounds
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
575.0
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
4
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
1
cLogP
-1.4
TPSA
219.93
Fraction CSP3
0.41
Chiral centers
2.0
Largest ring
6.0
QED
0.07
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Antibacterial
antibiotic
Bacterial
ERK
MEK
Raf
Ras
Pathway
Microbiology/virology
Anti-infection
GPCR/G protein
MAPK/ERK Pathway
Stem Cell/Wnt
Source data
