General
Preferred name
curcumin
Synonyms
NSC32982 ()
Diferuloylmethane ()
Natural Yellow 3 ()
Indian Saffron ()
Turmeric yellow ()
NSC-32982 ()
INS NO. 100(I) ()
Kurkum ()
Ci 75300 ()
E100 ()
Jianghuangsu ()
Kacha haldi ()
NSC-687842 ()
C.i. 75300 ()
E-100 ()
Haldar ()
CI-75300 ()
E 100 ()
Lipocurc ()
Curcumin e100 ()
C.i. natural yellow 3 ()
INS-100(I) ()
Merita earth ()
Nanocurc ()
P&D ID
PD011359
CAS
15845-47-3
8024-37-1
458-37-7
Tags
available
nuisance
probe
covalent binder
drug
natural product
Drug indication
Chronic lymphocytic leukemia
Solid tumour/cancer
Drug Status
approved
investigational
Max Phase
3.0
Probe info
Probe type
calculated probe
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Curcumin's physicochemical properties imply that it is an implausible clinical lead . It is unstable, reactive, and nonbioavailable, and has been identified as having attributes of both PAINS (pan-assay interference compounds) and IMPS (invalid metabolic panaceas) compounds. (GtoPdb)
PRICE 29
DESCRIPTION Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-¦ÊB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
DESCRIPTION Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 ??M) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.
DESCRIPTION Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant. (TargetMol Bioactive Compound Library)
Cell lines
111
Organisms
20
Compound Sets
18
Bioprocess diversity set
Cayman Chemical Bioactives
81025
ChEMBL Drugs
CHEMBL140
Concise Guide to Pharmacology 2023/24
7000
CovalentInDB
CI000144
CZ-OPENSCREEN Bioactive Library
DrugBank
DB11672
DrugBank Approved Drugs
DB11672
DrugMAP
DMQPH29
EU-OPENSCREEN Bioactive Compound Library
EOS100673
Guide to Pharmacology
7000
MedChem Express Bioactive Compound Library
HY-N0005
NIH Mechanistic Set
Nuisance compounds in cellular assays
Other bioactive compounds
Probe Miner (suitable probes)
P13726/1803882
ReFrame library
TargetMol Bioactive Compound Library
T1516
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
368.13
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
3.37
TPSA
93.06
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
3
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Nonspecific/NOS
Curcuminoids
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Biological process
Glycosylation & protein folding/targeting, cell wall biogenesis
Pathway
NF-¦ÊB
NF-??
Apoptosis
Autophagy
Chromatin/Epigenetic
DNA Damage/DNA Repair
Immunology/Inflammation
Microbiology/virology
Anti-infection
Epigenetics
NF-κB
Target
Epigenetic Reader Domain
Ferroptosis
Histone Acetyltransferase
Influenza Virus
Keap1-Nrf2
Mitophagy
p300 histone acetylatransferase
Source data