General
Preferred name
MAYTANSINE
Synonyms
NSC 153858 ()
NSC-153858 ()
Maitansina ()
Maitansine ()
P&D ID
PD011257
CAS
35846-53-8
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations[1].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
10
Organisms
0
Compound Sets
4
Cayman Chemical Bioactives
ChEMBL Drugs
MedChem Express Bioactive Compound Library
NIH Mechanistic Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
691.29
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
1
cLogP
3.53
TPSA
156.47
Fraction CSP3
0.59
Chiral centers
8.0
Largest ring
19.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Microtubule/Tubulin
Pathway
Cell Cycle/DNA Damage
cytoskeleton
Source data
