General
Preferred name
Thiazovivin
Synonyms
P&D ID
PD011183
CAS
1226056-71-8
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Thiazovivin is a potent ROCK inhibitor, which can protect human embryonic stem cells. Thiazovivin improves the efficiency of iPSC generation.
PRICE
80
DESCRIPTION
Thiazovivin, a ROCK inhibitor (IC50: 0.5 ??M), increases the survival rate of hESC.
DESCRIPTION
Histone deacetylase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
311.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
2.61
TPSA
79.8
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ROCK
ROCK inhibitor
hESC enhancer
Primary Target
Rho-Kinases
MOA
Inhibitor
rho associated kinase inhibitor
Pathway
Cell Cycle/DNA Damage
cytoskeleton
Stem Cell/Wnt
TGF-beta/Smad
Cell Cycle/Checkpoint
Cytoskeletal Signaling
Stem Cells
Source data
