General
Preferred name
SAFINAMIDE MESYLATE
Synonyms
EMD 1195686 mesylate ()
FCE28073 mesylate ()
Safinamide (mesylate) ()
FCE 26743 (mesylate) ()
EMD 1195686 (mesylate) ()
PNU-151774E,FCE28073 ()
Safinamide (mesylate) ()
Safinamide methansulfonate ()
EMD 1195686 ()
NW-1015 ()
Safinamide methanesulfonate ()
Xadago ()
Safinamide mesilate ()
PNU-151774E ()
NW 1015 ()
PNU 151774E ()
P&D ID
PD011178
CAS
202825-46-5
Tags
available
drug
Drug indication
Parkinson disease
Drug Status
approved
Max Phase
4.0
First approval
2015
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Safinamide (FCE 26743; EMD 1195686) mesylate is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 ¦ÌM) over MAO-A (IC50=580 nM)[1]. Safinamide mesylate also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 ¦ÌM) than at resting (IC50=262 ¦ÌM) potentials. Safinamide mesylate has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke et.al[2][3].
PRICE
40
DESCRIPTION
Safinamide mesylate (EMD 1195686 mesylate) , a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivity against MAO-A.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
398.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
1.87
TPSA
118.72
Fraction CSP3
0.28
Chiral centers
1.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Neuroscience
Neuronal Signaling
MOA
MAO
Target
Monoamine Oxidase
Source data
