General
Preferred name
Y-27632 dihydrochloride
Synonyms
Y-27632 2HCl ()
Y 27632 dihydrochloride ()
Y-27632 (dihydrochloride) ()
Y-27632 (hydrochloride) ()
P&D ID
PD011158
CAS
129830-38-2
146986-50-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor (ROCK-I Ki=220 nM; ROCK-II Ki=300 nM). Y-27632 dihydrochloride shows antiepileptic effects[1][2][3][4].
PRICE 43
DESCRIPTION Selective p160ROCK inhibitor (Tocriscreen Total)
DESCRIPTION Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. (TargetMol Bioactive Compound Library)
DESCRIPTION Glucosidase I and II inhibitor (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
8
Axon Medchem Screening Library
1683
Cayman Chemical Bioactives
10005583
EU-OPENSCREEN Bioactive Compound Library
EOS101041
MedChem Express Bioactive Compound Library
HY-10583
Selleckchem Bioactive Compound Library
Y-27632
TargetMol Bioactive Compound Library
T1725
Tocris Bioactive Compound Library
1254
Tocriscreen Total
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
319.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
3.02
TPSA
68.01
Fraction CSP3
0.57
Chiral centers
1.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
ROCK
ROCK1 (p160ROCK)
ROCK2
ROCK inhibitor
Autophagy,ROCK
Organoid
Primary Target
Rho-Kinases
MOA
Inhibitor
Pathway
Cell Cycle/DNA Damage
cytoskeleton
Stem Cell/Wnt
TGF-beta/Smad
Cell Cycle/Checkpoint
Cytoskeletal Signaling
Stem Cells
Source data