General
Preferred name
SL 327
Synonyms
SL-327 ()
SL327 ()
MEK1/2 inhibitor ()
P&D ID
PD011155
CAS
305350-87-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION High affinity competitive prolyl-tRNA synthetase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Selective inhibitor of MEK1 and MEK2; brain penetrant (Tocriscreen Total)
DESCRIPTION SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions. Additionally, although SL327 caused a generalized depression of locomotor activity, it did not prevent the development of EtOH-sensitization. (BOC Sciences Bioactive Compounds)
Compound Sets
11
Axon Medchem Screening Library
1122
BOC Sciences Bioactive Compounds
sl327-cas-305350-87-2-369532
Cayman Chemical Bioactives
15598
DrugMAP
DMYJV4I
EU-OPENSCREEN Bioactive Compound Library
EOS101027
Guide to Pharmacology
6008
MedChem Express Bioactive Compound Library
HY-15437
Selleckchem Bioactive Compound Library
SL327
Tocris Bioactive Compound Library
1969
Tocriscreen Total
ZINC Tool Compounds
ZINC000001910234
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
335.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
4.23
TPSA
75.83
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
MEK
MOA
Inhibitor
Target
MEK inhibitor
Pathway
MAPK/ERK Pathway
Source data