General
Preferred name
SB 203580
Synonyms
SB-203580 ()
SB 203580 hydrochloride ()
RWJ 64809 ()
PB 203580 ()
SB203580 ()
Adezmapimod (hydrochloride) ()
Adezmapimod ()
SB 203580 (hydrochloride) ()
RWJ 64809 (hydrochloride) ()
Adezmapimod (SB203580) ()
RWJ 64809, PB 203580 ()
P&D ID
PD011151
CAS
152121-47-6
869185-85-3
Tags
drug candidate
natural product
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SB203580 inhibits p38 MAPK enzymes, with some selectivity for p38α. The compound has been used to dissect the p38 signalling pathway and to determine the binding mode and differentiate functions between the four p38 MAP kinase homologues . The hydrochloride salt is water-soluble. (GtoPdb)
DESCRIPTION Selective inhibitor of p38 MAPK (Tocriscreen Plus)
DESCRIPTION MEK inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Selective inhibitor of BTK (Tocris Bioactive Compound Library)
DESCRIPTION Selective inhibitor of p38 MAPK (Tocriscreen Total)
DESCRIPTION Selective inhibitor of p38 MAPK; water-soluble (Tocriscreen Total)
DESCRIPTION SB 203580 hydrochloride is a water-soluble form of the potent MAP kinase inhibitor SB 203580 with IC50 values of 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. It was shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. (BOC Sciences Bioactive Compounds)
Cell lines
5
Organisms
3
Compound Sets
22
AdooQ Bioactive Compound Library
A10824
Axon Medchem Screening Library
1465
1363
BOC Sciences Bioactive Compounds
sb203580-hydrochloride-cas-869185-85-3-item-286145
Cayman Chemical Bioactives
13344
13067
DrugMAP
DMAET6F
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100631
EUbOPEN Chemogenomics Library
Guide to Pharmacology
5269
JUMP-Target 1 Compound Set
176155
Ki Database
SB203580
LINCS compound set
10167-101
10167-999
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL10
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL10
MedChem Express Bioactive Compound Library
HY-10256A
HY-10256
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
SB-203580
TargetMol Bioactive Compound Library
T1764
Tocris Bioactive Compound Library
1402
1202
Tocriscreen Plus
1202
Tocriscreen Total
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
377.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
4.68
TPSA
58.64
Fraction CSP3
0.05
Chiral centers
1.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
MAPK
Autophagy
MAPK/ERK Pathway
Target
p38 MAPK
p38 MAPK inhibitor
MAPK14
Mitophagy
Mitophagy,p38 MAPK
MOA
Inhibitor
Stress-Activated Protein (SAP/Jun) Kinase Inhibitors
Calcium Channel Activators
p38 MAPK Inhibitors
Member status
member
Solubility
Ethanol: 30 mg/ml
DMSO: 30 mg/ml
DMF: 30 mg/ml
Source data