General
Preferred name
RUCAPARIB PHOSPHATE
Synonyms
AG-014699 ()
PF-01367338 ()
PF-01367338 phosphate ()
AG-014699 phosphate ()
AG 014699 ()
Rucaparib (phosphate) ()
AG-014699 (phosphate) ()
PF-01367338 (phosphate) ()
Rucaparib (AG-014699) phosphate ()
AG-14699 ()
AG014699 ()
PF01367338 ()
P&D ID
PD011140
CAS
459868-92-9
283173-50-2
Tags
available
drug candidate
Drug Status
investigational
Max Phase
Phase 1
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Rucaparib Phosphate is a selective PARP inhibitor that suppresses the PARP1-mediated DNA repair via binding to PARP1 (Ki = <5 nM). It can be used to sensitize cancer cells to chemotherapy as an antineoplastic agent.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
421.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
6
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
2.05
TPSA
134.68
Fraction CSP3
0.21
Chiral centers
0.0
Largest ring
7.0
QED
0.36
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Genome integrity
Chromatin/Epigenetic
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Epigenetics
Target
PARP1, PARP2
PARP
PARP1 inhibitor
Source data