General
Preferred name
MLN8054
Synonyms
MLN-8054 ()
MLN 8054 ()
P&D ID
PD011139
CAS
869363-13-3
Tags
available
drug candidate
obsolete probe
Drug indication
pancreatic neoplasm
Solid tumour/cancer
Drug Status
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC50 of 4 nM.
PRICE
124
DESCRIPTION
MLN-8054 is an ATP-competitive (Type I), reversible inhibitor of Aurora kinases A, B and C with limited selectivity for A .
(GtoPdb)
DESCRIPTION
MLN8054 is an ATP-competitive and selective inhibitor of Aurora A kinase with IC50 = 1 nM.
(Enamine Bioactive Compounds)
DESCRIPTION
MLN8054 is an aurora kinase inhibitor MLN8054, which is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Auora kinase inhibitor MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregration, and inhibition of cell proliferation. Aurora A localizes in mitosis to the spindle poles and to spindle microtubules and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
10
Organisms
0
Compound Sets
19
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Clinical kinase drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
476.09
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
4
cLogP
5.87
TPSA
87.47
Fraction CSP3
0.04
Chiral centers
0.0
Largest ring
7.0
QED
0.38
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Targets
AURKA
Target
Aurora A
Aurora B
Aurora Kinase
CK2
LCK
PKA
MOA
Casein Kinase inhibitor
PKA inhibitor
Src inhibitor
Aurora Kinase inhibitor
Pathway
Angiogenesis
Cell Cycle/Checkpoint
Chromatin/Epigenetic
Metabolism
Stem Cells
Tyrosine Kinase/Adaptors
Cell Cycle/DNA Damage
Epigenetics
Therapeutic Class
Anticancer Agents
Source data
