General
Preferred name
JNJ-38877605
Synonyms
JNJ38877605 ()
JNJ 38877605 ()
P&D ID
PD011130
CAS
943540-75-8
Tags
available
drug candidate
probe
Drug indication
Solid tumour/cancer
Drug Status
investigational
Max Phase
Phase 1
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
High-quality chemical probes
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Cell lines
1
Organisms
0
Compound Sets
18
AdooQ Bioactive Compound Library
A10493
Cayman Chemical Bioactives
27650
ChEMBL Drugs
CHEMBL2133806
Clinical kinase drugs
Drug Repurposing Hub
DrugBank
DB13113
DrugMAP
DMDIPW8
EU-OPENSCREEN Bioactive Compound Library
EOS100373
High-quality chemical probes
PD011130
LINCS compound set
10156-101
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2133806
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL2133806
MedChem Express Bioactive Compound Library
HY-50683
Novartis Chemogenetic Library (NIBR MoA Box)
Probe Miner (suitable probes)
P08581/107778
ReFrame library
Selleckchem Bioactive Compound Library
JNJ-38877605
TargetMol Bioactive Compound Library
T6095
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
377.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
5
cLogP
3.21
TPSA
73.79
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Targets
MET
Pathway
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Target
c-Met
c-Met/HGFR
Member status
virtual
MOA
Inhibitors of Signal Transduction Pathways
HGFR (MET
c-Met) Inhibitors
tyrosine kinase inhibitor
Source data