General
Preferred name
Pilaralisib analogue
Synonyms
XL-147, SAR-245408 ()
SAR245408 ()
XL147 analogue ()
XL147 ()
PILARALISIB ()
XL-147 ()
SAR-245408 ()
XL147 analog ()
P&D ID
PD011126
CAS
956958-53-5
1033110-57-4
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Pilaralisib is an orally bioavailable small molecule inhibitor of the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Clinical kinase drugs
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
448.08
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
5
cLogP
4.49
TPSA
109.76
Fraction CSP3
0.05
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
PIK3CA,PIK3CD,PIK3CG
Pathway
DNA Damage/DNA Repair
PI3K/Akt/mTOR signaling
Apoptosis
PI3K/Akt/mTOR
Target
DNA-PK
PI3K??
PI3K¦Á
PI3K¦Â
PI3K¦Ã
PI3K¦Ä
PIK3CA, PIK3CD, PIK3CG
PI3K
Apoptosis related,PI3K
MOA
DNA-PK inhibitor
PI3K inhibitor
Therapeutic Class
Anticancer Agents
Source data
