General
Preferred name
AT9283
Synonyms
AT-9283 ()
J-504568 ()
AT 9283 ()
4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM ()
At 9283 ()
P&D ID
PD011121
CAS
896466-04-9
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Drug Status
experimental
investigational
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Cell lines
8
Organisms
0
Compound Sets
15
Axon Medchem Screening Library
2219
Cayman Chemical Bioactives
11496
ChEMBL Drugs
CHEMBL495727
Clinical kinase drugs
Drug Repurposing Hub
DrugBank
DB05169
DB08067
DrugMAP
DMQ94CT
EU-OPENSCREEN Bioactive Compound Library
EOS100746
LINCS compound set
10393-101
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL495727
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL495727
MedChem Express Bioactive Compound Library
HY-50514
ReFrame library
Selleckchem Bioactive Compound Library
AT9283
TargetMol Bioactive Compound Library
T3068
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
381.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
3
cLogP
2.07
TPSA
110.96
Fraction CSP3
0.42
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
JAK2,JAK3
Pathway
Angiogenesis
Cell Cycle/Checkpoint
Chromatin/Epigenetic
Cytoskeletal Signaling
Tyrosine Kinase/Adaptors
JAK/STAT Signaling
Stem Cells
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Epigenetics
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Target
Aurora A
Aurora B
Abl1 (T315I)
JAK2
JAK3
AURKA, AURKB, JAK2, JAK3, RPS6KA6, STK17A
Aurora/JAK inhibitor
Aurora Kinase
Bcr-Abl
FLT3
JAK
Aurora Kinase,Bcr-Abl,JAK
MOA
Bcr-Abl inhibitor
Aurora kinase inhibitor, JAK inhibitor
Therapeutic Class
Anticancer Agents
Source data