General
Preferred name
GANETESPIB
Synonyms
STA-9090 ()
STA 9090 ()
Ganetespib (STA-9090) ()
P&D ID
PD011109
CAS
888216-25-9
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
small cell lung carcinoma
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ganetespib (STA-9090) is a small molecule pan-HSP90 inhibtor . It has pro-apoptotic and anti-proliferative actions in a range of cancer cell types . Ganetespib has been proposed as a senolytic compound that is able to promote cell death in AR-induced senescent prostate cancer cells . (GtoPdb)
DESCRIPTION Ganetespib (STA-9090) is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Ganetespib has antiangiogenic effects in colorectal cancer mediated through inhibition of HIF-1¦Á and STAT3[1][2][3][4][5][6].
PRICE 73
DESCRIPTION Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90), exhibiting potential antineoplastic activity. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
0
Compound Sets
14
Axon Medchem Screening Library
1968
ChEMBL Drugs
CHEMBL2103879
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12047
EU-OPENSCREEN Bioactive Compound Library
EOS100757
Guide to Pharmacology
13309
JUMP-Target 1 Compound Set
LINCS compound set
10374-101
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2103879
MedChem Express Bioactive Compound Library
HY-15205
ReFrame library
Selleckchem Bioactive Compound Library
ganetespib-sta-9090
TargetMol Bioactive Compound Library
T2309
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
364.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
4
cLogP
3.25
TPSA
96.07
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
HSP
HSP90
HIF-1α
HSP90AA1
HSP90 inhibitor
Apoptosis related,HSP (HSP90)
MOA
HSP inhibitor
Pathway
Angiogenesis
Chromatin/Epigenetic
Cytoskeletal Signaling
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Source data