General
Preferred name
ABT-751
Synonyms
ABT 751 ()
E-7010 ()
E7010 ()
ABT-751 (E7010) ()
NSC-742134 ()
E 7010 ()
P&D ID
PD011108
CAS
857447-92-8
141430-65-1
Tags
available
nuisance
drug candidate
Drug indication
Solid tumour/cancer
Neuroblastoma
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on ¦Â-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis, thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer[1][2][3][4][5][6][7][8].
PRICE
50
DESCRIPTION
Inhibitor of microtubule polymerization; antimitotic and antitumor
(Tocriscreen Plus)
DESCRIPTION
ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
30
Organisms
1
Compound Sets
15
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
LINCS compound set
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
371.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.34
TPSA
100.55
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.57
Structural alerts
1
Tubulin modulation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Target
TUBB
Apoptosis
Microtubule/Tubulin
Microtubule Associated
Microtubule
MOA
tubulin polymerization inhibitor
Pathway
Autophagy
Cytoskeletal Signaling
Cell Cycle/DNA Damage
cytoskeleton
Source data
