General
Preferred name
BIIB021
Synonyms
BIIB 021 ()
CNF2024 ()
BIIB-021 ()
CNF 2024 ()
94M ()
cpd 20 ()
CNF-2024 ()
Cnf2024 ()
Cf1983 ()
P&D ID
PD011103
CAS
848695-25-0
Tags
available
probe
drug candidate
Drug indication
Breast cancer
Lymphoma
Drug Status
investigational
Max Phase
2.0
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This reference looks at the specificity of HSP90 inhibitors . BIIB021, that exhibits antitumour activity in preclinical models, has maximum (2nM) potency against HSP90α (HSP90AA1) but cross-reacts between the four paralogues tested .
DESCRIPTION This reference looks at the specificity of HSP90 inhibitors . BIIB021 exhibits antitumour activity in preclinical models, has maximum (2nM) potency against HSP90α (HSP90AA1) but cross-reacts between the four paralogues tested . (GtoPdb)
DESCRIPTION BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively[1].
PRICE 47
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION DNA alkylating agent; cytotoxic and antineoplastic (Tocris Bioactive Compound Library)
DESCRIPTION Selective Hsp90 inhibitor (Tocriscreen Plus)
DESCRIPTION BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM). (TargetMol Bioactive Compound Library)
Cell lines
16
Organisms
0
Compound Sets
18
AdooQ Bioactive Compound Library
A10143
Axon Medchem Screening Library
1543
Cayman Chemical Bioactives
18269
ChEMBL Drugs
CHEMBL467399
Chemical Probes.org
biib021
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12359
DrugMAP
DMPAJ41
EU-OPENSCREEN Bioactive Compound Library
EOS101518
Guide to Pharmacology
9258
High-quality chemical probes
PD011103
MedChem Express Bioactive Compound Library
HY-10212
ReFrame library
Selleckchem Bioactive Compound Library
BIIB021
TargetMol Bioactive Compound Library
T2286
Tocris Bioactive Compound Library
4608
Tocriscreen Plus
4608
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
318.1
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
2.13
TPSA
91.74
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Pathway
Autophagy
Cytoskeletal Signaling
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Primary Target
Hsp90
MOA
Inhibitor
HSP inhibitor
Target
HSP90AA1
HSP90 inhibitor
HSP (HSP90)
HSP90AA1, HSP90AB1
HSP
HSP90
Orthogonal probe
Onalespib
Target subclass
Chaperone
Chaperone, Chaperone
Target class
Other post-translational modification
Other post-translational modification, Other post-translational modification
Source data