General
Preferred name
BIIB021
Synonyms
BIIB 021 ()
BIIB-021 ()
CNF2024 ()
CNF 2024 ()
94M ()
cpd 20 ()
CNF-2024 ()
Cnf2024 ()
P&D ID
PD011103
CAS
848695-25-0
Tags
available
drug candidate
probe
Drug indication
Breast cancer
Drug Status
investigational
Max Phase
Phase 2
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This reference looks at the specificity of HSP90 inhibitors . BIIB021 exhibits antitumour activity in preclinical models, has maximum (2nM) potency against HSP90α (HSP90AA1) but cross-reacts between the four paralogues tested . (GtoPdb)
DESCRIPTION This reference looks at the specificity of HSP90 inhibitors . BIIB021, that exhibits antitumour activity in preclinical models, has maximum (2nM) potency against HSP90α (HSP90AA1) but cross-reacts between the four paralogues tested .
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION Selective Hsp90 inhibitor (Tocriscreen Plus)
DESCRIPTION DNA alkylating agent; cytotoxic and antineoplastic (Tocris Bioactive Compound Library)
Cell lines
12
Organisms
0
Compound Sets
17
AdooQ Bioactive Compound Library
A10143
Axon Medchem Screening Library
1543
Cayman Chemical Bioactives
18269
ChEMBL Drugs
CHEMBL467399
Chemical Probes.org
biib021
Drug Repurposing Hub
DrugBank
DB12359
DrugMAP
DMPAJ41
EU-OPENSCREEN Bioactive Compound Library
EOS101518
Guide to Pharmacology
9258
High-quality chemical probes
PD011103
MedChem Express Bioactive Compound Library
HY-10212
ReFrame library
Selleckchem Bioactive Compound Library
BIIB021
TargetMol Bioactive Compound Library
T2286
Tocris Bioactive Compound Library
4608
Tocriscreen Plus
4608
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
318.1
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
2.13
TPSA
91.74
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Pathway
Cytoskeletal Signaling
Metabolism
Autophagy
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Target
HSP90
HSP90AA1
HSP90 inhibitor
HSP
HSP (HSP90)
HSP90AA1, HSP90AB1
Primary Target
Hsp90
MOA
Inhibitor
HSP inhibitor
Orthogonal probe
Onalespib
Target subclass
Chaperone
Chaperone, Chaperone
Target class
Other post-translational modification
Other post-translational modification, Other post-translational modification
Source data