General
Preferred name
Chromanol 293B
Synonyms
(-)-[3R,4S]-Chromanol 293B ()
(3R,4S)-293B ()
3S,4R-293B ()
(3R,4S)-293B ()
3S,4R-293B ()
P&D ID
PD011069
CAS
163163-24-4
163163-23-3
163163-25-5
Tags
drug candidate
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(3R,4S)-293B acts as an antagonist of the KCNQ1 potassium channel (Kv7.1). The stereo-specific effects of the (3R,4S)-293B and enantiomers has been reported by Seebohm et al. (2001) . Note that some biological activity data may have been generated using the racemic mixture (chromanol 239B) represented by the 'flat' structure with PubChem CID 656731. Additional partially specified stereo-isomers include CID 44275282 and CID 44275281.
(GtoPdb)
DESCRIPTION
Chromanol 293B is a selective blocker of the slow delayed rectifier K+ current (IKs) with IC50 of 1-10 ¦ÌM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC50 of 19 ¦ÌM[1].
DESCRIPTION
This is an alternative enantiomer of . The stereo-specific effects of this ligand and the enantiomer has been reported by Seebohm et al. (2001) . Note that some biological activity data may have been generated using the racemic mixture (chromanol 239B) represented by the 'flat' structure with PubChem CID 656731. Additional partially specified stereo-isomers include CID 44275282 and CID 44275281.
(GtoPdb)
DESCRIPTION
Potent and selective NMDA antagonist; acts at glycine site
(Tocris Bioactive Compound Library)
DESCRIPTION
IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)
(Tocriscreen Total)
DESCRIPTION
(-)-[3R,4S]-Chromanol 293B is one of the chromanols, which inhibits cAMP-mediated Cl- secretion in colon crypts by a blockade of a cAMP-activated K+ conductance. It selectively inhibits the slow component of delayed rectifier K+ current. It has negligible inhibitory action at KV11.1 (hERG) channels. It may be a useful research chemical.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
324.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
1.41
TPSA
90.63
Fraction CSP3
0.53
Chiral centers
2.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Voltage-gated Potassium (KV) Channels
MOA
Blocker
potassium channel blocker
Target
KCNQ blocker
CFTR
Potassium Channel
Pathway
Membrane Transporter/Ion Channel
Source data
