General
Preferred name
COSTUNOLIDE
Synonyms
(+)-Costunolide ()
NSC 106404 ()
Costus lactone ()
Costus lactone(+)-Costunolide ()
P&D ID
PD011023
CAS
553-21-9
Tags
available
covalent binder
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3].
PRICE
45
DESCRIPTION
Inhibitor of human telomerase activity
(Tocriscreen Total)
DESCRIPTION
Costunolide (Costus lactone) has anti-inflammatory and anti-oxidant properties and mediates apoptosis.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
12
Organisms
0
Compound Sets
8
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
232.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
0
cLogP
3.55
TPSA
26.3
Fraction CSP3
0.53
Chiral centers
2.0
Largest ring
10.0
QED
0.36
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Endogenous Metabolite
FPTase
Telomerase (MCF-7)
Telomerase (MDA-MB-231)
Primary Target
Telomerase
MOA
Inhibitor
Telomerase inhibitor
Pathway
DNA Damage/DNA Repair
Metabolism
Metabolic Enzyme/Protease
Source data
