General
Preferred name
VADIMEZAN
Synonyms
DMXAA ()
ASA-404 ()
NSC-640488 ()
NSC 640488 ()
5,6-Dimethylxanthenone-4-acetic Acid ()
DMXAA (ASA404) ()
Vadimezan (ASA404) ()
NSC 640488, DMXAA ()
AS-1404 ()
ASA404 ()
P&D ID
PD010981
CAS
117570-53-3
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Negative control for (+)-JQ1
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
7
Organisms
0
Compound Sets
13
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
282.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
3.19
TPSA
67.51
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Angiogenesis
Anti-infection
Immunology/Inflammation
Target
DT-diaphorase
IFNAR
Influenza Virus
STING
Antiviral,IFN,STING,TNF-alpha,VDA
Primary Target
STING-Dependent Signaling
MOA
Agonist
Mouse STING agonist
Interferon Inducers
Vascular Disrupting Agents (VDA)
angiogenesis inhibitor
Member status
virtual
Source data
