General
Preferred name
esflurbiprofen
Synonyms
(S)-(+)-Flurbiprofen ()
(S)-Flurbiprofen ()
FLURBIPROFEN ()
Flurbiprofen, (s)- ()
BTS 24332 ()
Esflurbiprofeno ()
BTS-24332 ()
Esflurbiprofene ()
P&D ID
PD010952
CAS
51543-39-6
5104-49-4
Tags
available
drug
Approved by
PMDA
First approval
2015
Drug indication
sprain
Osteoarthritis
Myalgia
Scapulohumeral periarthritis
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Esflurbiprofen is a topically applied, non-steroidal anti inflammatory drug (NSAID). It is the more active enantiomer of racemic .
(GtoPdb)
DESCRIPTION
(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 ¦ÌM and 0.47 ¦ÌM for COX-1 and COX-2, respectively[1].
PRICE
29
DESCRIPTION
Esflurbiprofen is an inhibitor of COX-1 and COX-2.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
244.09
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
3.68
TPSA
37.3
Fraction CSP3
0.13
Chiral centers
1.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
COX-1
COX-2
PGE synthase
PTGS1, PTGS2
Immunology & Inflammation related
Indication
rheumatoid arthritis, osteoarthritis
MOA
cyclooxygenase inhibitor
Pathway
Immunology/Inflammation
Neuroscience
Source data
