General
Preferred name
AZD-5438
Synonyms
AZD 5438 ()
AZD5438 ()
KIN001-239 ()
AZD 5438 ()
P&D ID
PD010916
CAS
602306-29-6
Tags
available
drug candidate
Drug indication
Neoplasm
Solid tumour/cancer
Drug Status
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
AZD5438 is a potent oral inhibitor of cyclin dependent kinases (CDKs) 1, 2 and 9 .
(GtoPdb)
DESCRIPTION
AZD-5438 is a potent CDK1, CDK2, and CDK9 inhibitor, with IC50s of 16 nM, 6 nM, and 20 nM in cell-free assays, respectively. AZD-5438 shows less inhibition activity against GSK3¦Â, CDK5 and CDK6;[1].
PRICE
53
DESCRIPTION
Class III PI 3-kinase inhibitor; also inhibits autophagy
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor
(Tocriscreen Plus)
DESCRIPTION
AZD5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol/L, respectively). Broad cdk inhibition may provide an effective method to impair the dysregulated cell cycle that drives tumorigenesis and AZD5438 has the pharmacologic profile that provides an ideal probe to test this premise.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
7
Organisms
5
Compound Sets
22
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CDK inhibitor database (CDKiDB)
ChEMBL Drugs
Clinical kinase drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LINCS compound set
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Pathogen Box
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
371.14
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
3.38
TPSA
89.77
Fraction CSP3
0.28
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Disease
KINETOPLASTIDS
Targets
CDK1,CDK2,CDK9
Target
CDK
CDK1
CDK2
CDK9
KCNH2
CDK(1/2/9) inhibitor
Primary Target
Cyclin-Dependent Protein Kinases
MOA
Inhibitor
CDK inhibitor
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
Source data
