General
Preferred name
URB597
Synonyms
CHEMBL184238 ()
URB 597 ()
KDS-4103 ()
FAAH Inhibitor II ()
Org-231295 ()
URB-597 ()
P&D ID
PD010909
CAS
546141-08-6
Tags
available
probe
covalent binder
drug candidate
Drug indication
Anxiety disorder
Schizophrenia
Drug Status
investigational
Max Phase
1.0
Probe info
Probe type
calculated probe
Probe sources
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
4
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
URB597 is an irreversible inactivator of fatty acid amide hydrolase (FAAH) with activity against FAAH2 .
(GtoPdb)
DESCRIPTION
URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity[1].
PRICE
41
DESCRIPTION
Potent, selective LRRK2 inhibitor; brain penetrant
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent and selective FAAH inhibitor
(Tocriscreen Plus)
DESCRIPTION
URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
338.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.87
TPSA
81.42
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Anandamide amidohydrolase
FAAH, FAAH2, TRPA1
FAAH
Mitophagy
Primary Target
Fatty Acid Amide Hydrolase
MOA
Inhibitor
Fatty Acid Amide Hydrolase (FAAH) Inhibitors
TRPA1 Agonists
FAAH inhibitor
Member status
virtual
Pathway
Autophagy
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
