General
Preferred name
Flavopiridol hydrochloride
Synonyms
ALVOCIDIB HYDROCHLORIDE ()
Flavopiridol HCl ()
MDL 107826A ()
NSC 649890 ()
HL 275 ()
NSC 649890 HCl ()
Flavopiridol (Hydrochloride) ()
Flavopiridol (L86-8275) HCl ()
NSC 649890, Alvocidib, HMR-1275, DSP-2033 ()
MDL-107826A ()
HMR 1275 ()
L-86-8275 ()
L 86 8275 ()
Alvocidib (Hydrochloride) ()
L86-8275 (Hydrochloride) ()
HMR-1275 (Hydrochloride) ()
P&D ID
PD010889
CAS
131740-09-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cyclin-dependent kinase inhibitor (Tocriscreen Plus)
DESCRIPTION JAK3 kinase inhibitor. Also inhibits EGFR (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
9
AdooQ Bioactive Compound Library
A11045
Cayman Chemical Bioactives
10009197
ChEMBL Drugs
CHEMBL2105698
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
HY-10006
Selleckchem Bioactive Compound Library
flavopiridol-hydrochloride
TargetMol Bioactive Compound Library
T2615
Tocris Bioactive Compound Library
3094
Tocriscreen Plus
3094
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
437.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
3
cLogP
3.73
TPSA
94.14
Fraction CSP3
0.29
Chiral centers
2.0
Largest ring
6.0
QED
0.56
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific/NOS
Flavonoid
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Cell Cycle/Checkpoint
Anti-infection
Autophagy
Cell Cycle/DNA Damage
Target
CDK1
CDK2
CDK4
CDK6
CDK7
CDK
HIV
Autophagy,CDK,HIV
Primary Target
Cyclin-Dependent Protein Kinases
MOA
Inhibitor
Source data