DESCRIPTION A-769662 is a small molecule activator of AMP-activated protein kinase (AMPK). Its chemical structure was originally disclosed by Cool et al. (2006) , in which it was used to demonstrate that AMPK activation is a feasible approach for the treatment of the metabolic syndrome and type 2 diabetes. A-769662 activates AMPK both allosterically (as evidenced by its ability to activate a mutant AMPK γ subunit that is resistant to endogenous AMP-induced activation) and by inhibiting dephosphorylation of AMPK on Thr172 . A-769662 is suitable as as experimental tool to understand the physiological roles of AMPK in vitro and in vivo. Use of A-769662 has also confirmed AMPK's role as an autophagy target, whose activation is able to ameliorate neurodegeneration in animal models . AMPK activation induces autophagy in an mTOR-independent manner, so limits the risk of the potentially detrimental effects that mTOR inhibition may have on important cellular pathways in addition to autophagy. (GtoPdb)

PRICE 60

DESCRIPTION A-769662 is an effective, reversible AMPK activator(EC50=0.8 ??M).

DESCRIPTION Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor (Tocris Bioactive Compound Library)

DESCRIPTION Potent AMPK activator (Tocriscreen Total)

DESCRIPTION A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity. (BOC Sciences Bioactive Compounds)

DESCRIPTION A-769662 is a potent, reversible adenosine 5'-monophosphate-activated protein kinase activator. (Enamine Bioactive Compounds)

DESCRIPTION A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM). (TargetMol Bioactive Compound Library)