General
Preferred name
SAPITINIB
Synonyms
AZD-8931 ()
AZD8931 diFuMaric acid ()
AZD8931 ()
Sapitinib (AZD8931) ()
AZD 8931 ()
P&D ID
PD010834
CAS
848942-61-0
1196531-39-1
Tags
available
drug candidate
Drug indication
Breast cancer
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sapitinib is an inhibitor of all members of the epidermal growth factor receptor (EGFR) receptor tyrosine kinase family and was investigated as a potential oncology therapeutic. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Clinical kinase drugs
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
473.16
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
3
cLogP
3.76
TPSA
88.61
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
EGFR,ERBB2,ERBB3
Pathway
Angiogenesis
JAK/STAT Signaling
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Target
EGFR
ERBB2
ERBB3
HER2/ErbB2
EGFR, ERBB2, ERBB3
ErbB4
EGFR,HER2
MOA
EGFR inhibitor
Source data
