General
Preferred name
AZ-960
Synonyms
AZ 960 ()
AZ960 ()
P&D ID
PD010824
CAS
905586-69-8
Tags
available
drug candidate
probe
Drug indication
Discovery agent
Probe info
Probe type
experimental probe
P&D approved
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
41
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Inhibitor;ATP Competitive
DESCRIPTION
AZ960 is a novel ATP competitive Janus kinase 2 (JAK2) inhibitor .
(GtoPdb)
DESCRIPTION
AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.
PRICE
159
MOA
Inhibitor
(Chemical Probes.org)
DESCRIPTION
AZ-960 is an ATP-competitive inhibitor of JAK2 with Ki value of 0.45 nM. It inhibits proliferation in a SET-2 human megakaryoblastic cell line harboring the JAK2V617F mutation with GI50 value of 33 nM.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
13
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Chemical Probes.org
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
High-quality chemical probes
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
354.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
4.18
TPSA
89.42
Fraction CSP3
0.17
Chiral centers
1.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
JAK
JAK2
Parasite
Virus Protease
JAK2 Inhibitor
Apoptosis related,JAK
MOA
JAK inhibitor
Pathway
Angiogenesis
Chromatin/Epigenetic
JAK/STAT Signaling
Microbiology/virology
Stem Cells
Tyrosine Kinase/Adaptors
Anti-infection
Epigenetics
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Orthogonal probe
BMS-911543
Target class
Protein kinase
Kinase
Solubility
Soluble in DMSO
Target subclass
TK
Source data
