General
Preferred name
DARIFENACIN HYDROBROMIDE
Synonyms
Darifenacin HBr ()
UK-88525 ()
Darifenacin (hydrobromide) ()
UK-88525 (hydrobromide) ()
Enablex ()
Uk-88525-04 (hbr) ()
UK-88525-04 (HYDROBROMIDE) ()
Emselex ()
P&D ID
PD010775
CAS
133099-07-7
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
urgency urinary incontinence
First approval
2004
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Darifenacin (UK-88525) hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin hydrobromide binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin hydrobromide can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin hydrobromide inhibits tumor growth in colorectal cancer cells and has anti-tumor effects[1][2][3][4][5][6].
PRICE
29
DESCRIPTION
Darifenacin is an M3 muscarinic receptor blocker used to treat urinary incontinence.
(Enamine Bioactive Compounds)
DESCRIPTION
Darifenacin hydrobromide (UK-88525) is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
506.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
3
cLogP
4.54
TPSA
55.56
Fraction CSP3
0.32
Chiral centers
1.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
M3 mAChR
mAChR
Akt
p38 MAPK
AChR
Pathway
Neuroscience
GPCR/G protein
MAPK/ERK Pathway
Neuronal Signaling
PI3K/Akt/mTOR
Source data
