General
Preferred name
DIOSMETIN
Synonyms
Luteolin 4-methyl ether ()
Flavonoid derivative 3 ()
Diosmetin-d3 ()
P&D ID
PD010735
CAS
520-34-3
1189728-54-8
Tags
available
drug
Approved by
FDA
Drug indication
Discovery agent
Drug Status
approved
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 ¦ÌM in HepG2 cell.
PRICE
29
DESCRIPTION
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
8
Organisms
0
Compound Sets
12
AdooQ Bioactive Compound Library
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
300.06
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
2.59
TPSA
100.13
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CYP1A1
Cytochrome P450
TrkB
CYP1B1
P450 (e.g. CYP17)
Indication
cosmetic
MOA
aryl hydrocarbon receptor agonist
Pathway
Metabolic Enzyme/Protease
Metabolism
Tyrosine Kinase/Adaptors
Source data
