General
Preferred name
PHA-767491
Synonyms
PHA 767491 hydrochloride ()
PHA767491 ()
CAY10572 ()
PHA 767491 ()
PHA767491 HCl ()
CAY10572 HCl ()
PHA-767491 HCl ()
CAY-10572 hydrochloride ()
Cdc7/Cdk9 Inhibitor ()
PHA-767491 (hydrochloride) ()
CAY10572, NMS 1116354 ()
PHA-767491 hydrochloride ()
compound 8 [PMID: 17480064] ()
P&D ID
PD010690
CAS
845714-00-3
942425-68-5
845538-12-7
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively.
PRICE 35
DESCRIPTION PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-?? and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1.
DESCRIPTION Compound 8 is reported in as an inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK-2; MAPKAPK2). Montagnoli et al. (2008) report the antitumour activity of this compound . (GtoPdb)
DESCRIPTION PHA-767491 is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively.
PRICE 41
DESCRIPTION MRN-ATM pathway inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION MK2 inhibitor; also inhibits cdc7/cdk9 (Tocriscreen Plus)
DESCRIPTION PHA-767491 hydrochloride is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor, which prevents initiation of DNA replication. It inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. It also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2). (BOC Sciences Bioactive Compounds)
DESCRIPTION PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1. (TargetMol Bioactive Compound Library)
DESCRIPTION PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. (BOC Sciences Bioactive Compounds)
DESCRIPTION PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively. (TargetMol Bioactive Compound Library)
Cell lines
20
Organisms
1
Compound Sets
21
AdooQ Bioactive Compound Library
A11164
Axon Medchem Screening Library
2690
BOC Sciences Bioactive Compounds
pha-767491-hydrochloride-cas-942425-68-5-item-84-463694
pha-767491-cas-845714-00-3-item-84-404690
Cayman Chemical Bioactives
18218
CDK inhibitor database (CDKiDB)
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB17043
DrugMAP
DM4H7D5
Enamine Bioactive Compounds
EBC-497111
EU-OPENSCREEN Bioactive Compound Library
EOS101257
Guide to Pharmacology
8763
LINCS compound set
10285-101
MedChem Express Bioactive Compound Library
HY-13461A
HY-13461
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
pha-767491
TargetMol Bioactive Compound Library
T6940
T6206
Tocris Bioactive Compound Library
3140
Tocriscreen Plus
3140
ZINC Tool Compounds
ZINC000016052718
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
213.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
1.36
TPSA
57.78
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Cdc7
CDK
CDK1
CDK2
CDK9
GSK-3β
Apoptosis
CDK1, RPS6KB1
CDC7/CDK9 inhibitor
Primary Target
MK2
MOA
Inhibitor
Inhibitors of Signal Transduction Pathways
Cell Division Cycle 7-Related Protein Kinase (CDC7) Inhibitors
CDC inhibitor
Member status
member
Pathway
Cell Cycle/Checkpoint
GPCR/G protein
PI3K/Akt/mTOR signaling
Stem Cells
Cell Cycle/DNA Damage
Source data