General
Preferred name
PF-04691502
Synonyms
PFE-PKIS 29 ()
PF4691502 ()
PF 04691502 ()
PFE-PKIS_29 ()
PF-4691502 ()
P&D ID
PD010689
CAS
1013101-36-4
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
breast neoplasm
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR. PF-04691502 binds to human PI3K¦Á, ¦Â, ¦Ä, ¦Ã and mTOR with Kis of 1.8, 2.1, 1.6, 1.9 and 16 nM, respectively.
PRICE
77
DESCRIPTION
PF-04691502 is an ATP-competitive dual PI3K/mTOR inhibitor. The discovery and structure of PF-04691502 is reported in . PubChem CID 25033539 shows the chemical structure without stereochemistry.
(GtoPdb)
DESCRIPTION
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Aurora kinase A and B inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
1
Compound Sets
25
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
Clinical kinase drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Kinase Chemogenomic Set (KCGS 08/2017, in progress)
Kinase Chemogenomic Set (KCGS)
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
425.21
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
2.25
TPSA
125.38
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
PIK3CA,PIK3CB,PIK3CD,PIK3CG,MTOR
Pathway
Autophagy
Cytoskeletal Signaling
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Primary Target
PI 3-kinase
MOA
Inhibitor
Mammalian Target of Rapamycin (mTOR
FRAP1) Inhibitors
Phosphatidylinositol 3-Kinase (PI3K) Inhibitors
mTOR inhibitor, PI3K inhibitor
Target
PIK3CG, PIK3CA, PIK3C2G, PIK3C2B, PIK3CD, PIK3CB, MTOR, PI4KB
MTOR, PIK3CA
PI3K/mTOR inhibitor
MTOR
PI3K
Akt,Apoptosis related,mTOR,PI3K
P-Akt (S473)
PI3Kα
PI3Kβ
PI3Kγ
PI3Kδ
Member status
member
Recommended Cell Concentration
None
Source data
